Targeting a cure

Our mission is to process and harmonize Alzheimer’s Disease genetic and genomic data to facilitate and expedite gene discovery and drug target identification.

Data Submission

NIAGADS guidelines and templates for data contribution to GCAD for harmonization with the Alzheimer’s Disease Sequencing Project dataset.

Raw Data AnalysisReadyData Data Processing VariantAnnotation QualityControl

From raw to analysis-ready data

Whole-genome and whole-exome sequencing data are processed into CRAMs, gVCFs and then joint called into project level VCFs.

Collaborating with researchers around the world

GCAD is facilitating collaborations between cohorts and researchers studying neurodegenerative diseases from all over the world.

Latest News

  • Join NIH “Community” Days to Learn About GDS Policy Updates Effective 1/25/25

    The National Institutes of Health (NIH) will be holding “Community Days” on: Registration is required. Please use the links above to register for the day you plan to attend. ASL will be provided. Who Should Attend: All researchers and their institutional officials who have access to or are planning to…

  • ADSP R5 WGS Preview Files are Here!

    Round 5 of the Alzheimer’s Disease Sequencing Project (NG00067v14) has been released! This release contains 22,158 new samples and 17 new cohorts, bringing the total number of genomes in the R5 release to 58,507 genomes from 57 cohorts. Files include the following: GCAD has implemented a new joint-genotype caller, GLnexus,…

  • ADSP Umbrella Dataset October 2024 Update: New Files Added to NG00067

    New files have been released in ng00067.v13 for the R2 20K Whole Exome Sequencing (WES) and R3 17K and R4 36K Whole Genome Sequencing (WGS). To apply for this dataset, see our application guide. For those who already have access to NG00067, files will be automatically available in compliance with…