Targeting a cure

Our mission is to process and harmonize Alzheimer’s Disease genetic and genomic data to facilitate and expedite gene discovery and drug target identification.

Data Submission

NIAGADS guidelines and templates for data contribution to GCAD for harmonization with the Alzheimer’s Disease Sequencing Project dataset.

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Raw Data AnalysisReadyData Data Processing VariantAnnotation QualityControl

From raw to analysis-ready data

Whole-genome and whole-exome sequencing data are processed into CRAMs, gVCFs and then joint called into project level VCFs.

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Collaborating with researchers around the world

GCAD is facilitating collaborations between cohorts and researchers studying neurodegenerative diseases from all over the world.

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Latest News

  • ADSP Releases Additional 19K Whole Genomes via NIAGADS DSS
    Posted on 10/10/2022

    On October 6, 2022, the Alzheimer’s Disease Sequencing Project (ADSP) released a new dataset comprised of 19,456 newly sequenced genomes together with joint genotype calls totaling 36,361 genomes with previously released genomes. The data release includes sequencing reads in the CRAM file format, individual sample genotype calls in the genomic…

  • ADSP releases quality-controlled whole-genome data on nearly 17,000 samples
    Posted on 10/29/2021

    NIAGADS is pleased to announce the release of the Release 3 (R3) WGS ADSP quality-controlled joint genotype called pVCF containing 16,905 samples. Additionally, this release includes a quality-controlled X-chromosome pseudoautosomal region (PAR) pVCF containing 20,503 whole exomes from Release 2 (R2) as well as R3 individual-level VCF structural variant (SV)…

  • ADSP Functional Genomics Consortium Launch
    Posted on 9/23/2021

    ADSP, the Alzheimer’s Disease Sequencing Project, has emerged as a powerful tool for genetics researchers in their work on genomics data analysis. This summer, NIA awarded six grants to fund projects that form the core of the ADSP Functional Genomics Consortium (FGC). This significant boost will support consortium researchers as they develop free and accessible tools, […]