Targeting a cure

Our mission is to process and harmonize Alzheimer’s Disease genetic and genomic data to facilitate and expedite gene discovery and drug target identification.

Data Submission

NIAGADS guidelines and templates for data contribution to GCAD for harmonization with the Alzheimer’s Disease Sequencing Project dataset.

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Raw Data AnalysisReadyData Data Processing VariantAnnotation QualityControl

From raw to analysis-ready data

Whole-genome and whole-exome sequencing data are processed into CRAMs, gVCFs and then joint called into project level VCFs.

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Collaborating with researchers around the world

GCAD is facilitating collaborations between cohorts and researchers studying neurodegenerative diseases from all over the world.

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Latest News

  • Important Update: NIAGADS DSS Login Changes
    Posted on 5/22/2026

    As part of NIH’s strengthened identity proofing requirements for accessing controlled-access data repositories (CADRs), we are introducing an important update to the login experience. This change is designed to enhance account security and ensure compliance with federal authentication standards (NOT-OD-25-159).  What to expect  Starting June 1, 2026, all users (PIs,…

  • ADSP Phenotype Harmonization Consortium Release 4 is Out!
    Posted on 3/12/2026

    The fourth release from the Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC), which includes harmonized phenotypes for ADSP participants with sequencing, is available in the ADSP Umbrella Dataset (NG00067v20). Importantly, this release includes harmonized diagnosis and plasma biomarkers for the first time. Existing users with approval for NG00067 will have access…

  • Attending ASHG 2025? See Us in Action!
    Posted on 10/14/2025

    Are you attending ASHG 2025 this week, 10/14/25-10/18/25, in Boston, MA, USA? The NIAGADS and GCAD team will be there presenting our work and in Booth 1345. See a schedule of where you can connect with our team below: Activity Type Wednesday, 10/15/25 Thursday, 10/16/25 Friday, 10/17/25 Talk Genomic Frontiers…